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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

The liver is one of the most vital organs in the human body, playing a crucial role in detoxification, metabolism, and overall health

The two-hit vascular hypothesis of Alzheimer's disease proposes that BBB dysfunction allows neurotoxins to enter the brain parenchyma, which in turn leads to neuroinflammation[43]