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Psychological factors influence real-world outcomes even when pharmacological mechanisms are superior

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Therefore the discovery of Leptin has been received with great expectation as a potential anti-obesity therapy due to its ability to reverse excess adiposity in animal models (rodents) characterized by a deficiency of the hormone, in fact, leptin reduces body weight dramatically, suppresses appetitive behaviors and improves other endocrine-sensitive and metabolic leptin abnormalities in children and adults with congenital hormone deficiency

Introduction Glutathione S -transferases (GSTs) refer to a group of cytosolic phase II detoxification enzymes, which have both a GSH-binding site and a substrate-binding site (H-site) that catalyze the nucleophilic attack of the sulfur atom of glutathione (GSH) on electrophilic groups of substrate molecules ( S -transferase Pi (GSTP) is the most abundant member of cytosolic GSTs in the mammalian cells ( via its non-catalytic ligand-binding activity