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Clinical concern regarding skeletal muscle changes during GLP-1RA therapy remains debated [40], and preclinical studies have reported context-dependent protection against muscle wasting in selected settings [42, 43]

MNTIs also share the production of melanin with some uncommon neuroblastic or neuronal tumors of the peripheral and central nervous system including esthesioneuroblastoma 12 , ganglioneuroblastoma 13 , neuroblastoma 14 , paraganglioma 15 , neurocytoma 16 and medulloblastoma 17

Imbalance in the composition of these important lipids is associated with several brain diseases 29

Depending on the nature of these glycation products, protein adducts or protein cross-linking are formed, giving rise to the AGEs [29]

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