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The Role of Oxidative Stress in Cognitive Decline How Free Radicals Damage Brain Cells Over Time Free radicals form naturally in your body, but when they accumulate, they cause oxidative stress

Thus, this region and its potential impact on the exact positioning of GSH might not have been under evolutionary pressure in class III GRXs

Similar to NADH, NADPH fulfills dual roles in cellular redox regulation: It is indispensable for antioxidant defense by facilitating GSH reduction yet simultaneously serves as a substrate for NADPH oxidases that generate ROS production (97)

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