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Apoptosis assay Apoptosis was evaluated via DNA fragmentation using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay following a previously described protocol [54]

Additionally, it has been demonstrated that IGF-I activated androgen receptor signaling in prostate cancer cells via the IGF-1R-forkhead box protein O1 (FOXO1) signaling axis, which is also implicated in castration-resistant prostate cancer (133135)

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98 The interaction between G-CSF and its receptor induces conformational changes within the receptors cytoplasmic domains, subsequently triggering the activation of multiple downstream signaling pathways (Fig

This method helps keep the peptide stable and ensures accurate, repeatable results