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2 The main process of metformin in the human body After oral administration of metformin, it enters the gastrointestinal (GI) tract and is absorbed by the intestinal epithelial cells of the upper small intestine

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2) Transfer of the Acyl Group to Carnitine : The enzyme Carnitine Palmitoyltransferase I (CPT-I), located on the outer mitochondrial membrane, facilitates the transfer of the acyl group from acyl-CoA to carnitine