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While EGFR family members can compensate IGF-IR inhibition and confer resistance to IGF-IR-targeted agents, IGF-IR can confer resistance to EGFR/ErbB2/ErbB3-targeted therapies as well

Perakakis N, Bornstein SR, Birkenfeld AL, et al

You may start to notice symptoms like increased thirst, fatigue, muscle cramps and headache

Cardiovascular considerations Both mazdutide and retatrutide improve cardiovascular risk markers, but the specifics differ in ways that matter for different patient populations