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In another experiment, where the middle femur of rats was sawed off by a wire saw, catalpol upregulates the expression of bone morphogenetic protein 2 (BMP-2), activates the Wnt/-catenin signaling pathway, and promotes femoral fracture healing in rats ( 2 O 2 by downregulating forkhead box O3 (FoxO3), activating the Wnt/-catenin signaling pathway, thereby improving cell viability, osteogenic differentiation, and inhibiting apoptosis ( Furthermore, catalpol can inhibit the ubiquitination and degradation of PTEN, block the NF-B and AKT signaling pathways, and prevent the differentiation of bone marrow-derived macrophages (BMMs) and RAW264.7 cells induced by receptor activator of nuclear factor kappa-B ligand (RANKL) into osteoclasts

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[8] Also DPP-4s are being studied for possible reduction in cardiovascular events

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