Mechanistically, GLP-1 receptor agonists may exert vascular protective effects by suppressing inflammation, limiting oxidative stress, and modulating key enzymes involved in extracellular matrix remodeling ( Matrix metalloproteinases, particularly MMP-9, together with their endogenous inhibitors (TIMPs), play central roles in extracellular matrix turnover and structural vascular remodeling ( The reduction in CRP, a recognized marker of aortic stiffness, medial degeneration, and systemic inflammation, further supports the anti-inflammatory profile associated with GLP-1RA therapy
Juan Franco, first author of one of the reviews and researcher at Heinrich Heine University Dsseldorf, Germany, affiliated with the Iberoamerican Cochrane Network
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Other clues are enlarged lymph nodes and/or symptoms related to other organs
