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doi: 10.1073/pnas.1205951109 66 XuYXuYZhuYSunHJuguilonCLiFet al

Oral delivery of heparin: SNAC and related formulations

This can be easily explained by the fact that NAC is often used concurrently with pro-oxidant agents and can reduce oxidative stress, most probably by reacting directly with them in the cell culture medium, and even when a pretreatment is declared, in most cases NAC is not washed away before the oxidative insult