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In many cases, these benefits outweigh the manageable risk of gastrointestinal side effects, especially when the medication is introduced gradually and monitored by a healthcare provider

Adequate hydration, fiber intake, and movement help mitigate this

308,362,363,372,434,435,436 Additionally, EULAR guidelines recommend losartan for patients with hypertension and fenofibrate for those with hyperlipidemia, both of which have mild uricosuric effects

After 64 weeks, participants taking oral semaglutide 25 mg achieved an average weight loss of 16.6% with full treatment adherence, compared to 2.7% with placebo

[13] Kalhori Z, Mehranjani MS, Azadbakht M, Shariatzadeh MA