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Active Transport The placenta contains a variety of transporters that can either facilitate or impede the passage of xenobiotics from the mother to the fetus (see Figure 3)

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Augmentation of IGF-I levels in the muscle increases AR clearance through the ubiquitin-proteasome system and AR phosphorylation by Akt[40], and in a mouse model of SBMA, muscle-specific overexpression of IGF-I was able to improve motor performance and body weight [40]

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