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Both were 72 week trials in overweight and obese patients with ATTAIN-1 being non-diabetics and ATTAIN-2 being in diabetics

G6PD is an essential enzyme in the pentose phosphate pathway (PPP), generating NADPH needed for cellular biosynthesis and reactive oxygen species (ROS) homeostasis, the latter especially key in red blood cells (RBCs)

By increasing appetite, THC can counteract the appetite-suppressing effect of GLP-1s, leading to an increase in calories consumed and making it harder to achieve weight loss

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This strongly suggests that a long-term effect of semaglutide is to enhance satiation (meal size) but not satiety (meal number)