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Consistently, HFD-fed mice lacking NKT cells exhibited increased weight gain, hepatic steatosis and inflammation, and accelerated fibrogenesis (153, 154)

Glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were performed ( n = 12 per group, per sex) to assess glucose metabolism and insulin sensitivity 46

The most parsimonious framing is a three-axis model: Transcriptional axis (GHK-Cu): upregulates VEGF, bFGF, collagen and elastin transcripts

156 Lysosomal enzymes produce autoantigens, alter the mucosal barrier, and increase cytokine secretions

Comparing them highlights the gulf between preclinical promise and clinical validation in peptide therapeutics