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Injection site reactions are a potential drawback, but many find the once-weekly schedule easier to manage

Notably, BMI and A1c were similar between cohorts at baseline and follow-up, suggesting the lower rates of nonexudative or any AMD with GLP-1 RAs are not readily explained by weight loss or glycemic control, though residual time-varying mediation cannot be excluded, this studys authors wrote in their paper

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Abstract Background A meta-analysis is presented of cardiovascular outcome trials (CVOTs) comparing glucagon-like peptide-1 receptor agonists (GLP-1RA) versus placebo on cardiorenal outcomes in patients with type 2 diabetes mellitus (T2DM)