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A comparative 8-week trial found GHK-Cu achieved 55.8% reduction in wrinkle volume versus control serum and outperformed Matrixyl 3000, a popular anti-aging peptide, by a substantial margin

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The dual-pathway approach engages both the GHRH axis (upstream stimulation of GH synthesis and release) and the ghrelin axis (amplification of GH pulse amplitude) simultaneously, which published preclinical data suggests produces greater GH elevation than either compound alone

In other cell types, arginine synthesis by citrulline is very low but dramatically increases when inducible nitric oxide synthase (NOS) increases (Fig