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p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

The trade-off is usually simple

However, the FDA label explicitly states that "it is unknown whether GLP-1 receptor agonists cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of GLP-1 receptor agonist-induced rodent thyroid C-cell tumors has not been determined." The rodent thyroid has substantially more C-cells than the human thyroid, and rodents may be more susceptible to this effect

In a multivariate model, the GLP-1-RA group was associated with 50% responder-rate at M6 (Fig