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This is metabolically transformed skin, and it requires a new formulation category with dedicated clinical evidence, specific active combinations, and regulatory positioning that distinguishes it from existing skincare segments

Proc Natl Acad Sci USA (2008) 105:725762

Feb 1 2021;4(2):e2036304

2009 Oct;19(5):426-31

Urine Relative Supersaturation (RSS) Evaluation Purpose To show that feeding BLUE Natural Veterinary Diet Kidney Support foods can result in clinically significant urine Relative Supersaturation (RSS) values less than 3 for calcium oxalate, which has been shown to limit the formation of calcium oxalate uroliths (See Figure 2)