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Oxidative Stress Is Not the Primary Mediator of Disease Pathology While tissue injury often increases ROS production and contributes to further damage, the primary pathological driver may not be oxidative stress, as it occurs in many cases secondary to other initiating factors (Figure 7)

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Overlapping vs Complementary Mechanisms Because these three compounds act on non-competing pathways, theyre often positioned in the literature as complementary rather than overlapping