Amylin analogs are challenging to manufacture because amylin is notoriously aggregation-prone, requiring specific amino-acid substitutions and synthesis controls
Retatrutide at 12 mg produced 24.2% body weight loss in phase 2 trials, the highest of any single-agent compound tested
However, GLP-1 is an effective anorexigenic peptide, inhibiting effectively food intake, even after prolong administration, indicating that this peptide could be a physiological regulator of food intake
In healthy humans, GIP has a circulating half-life of 7 min (Meier et al., 2004b), GLP-1 has a circulating half-life of 12 min (Deacon et al., 1995b), and GLP-2 has a circulating half-life of 7 min (Drucker et al., 1997
Published June 29, 2022