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When to seek medical advice : Patients should contact their GP, diabetes specialist nurse, or NHS 111 urgently if they experience: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Persistent vomiting (unable to keep down fluids for more than 24 hours) Signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Fever, jaundice, or right upper abdominal pain (possible gallbladder disease) If nausea significantly impacts their ability to maintain adequate nutrition These symptoms may warrant dose reduction, temporary treatment interruption, or switching to an alternative GLP-1 preparation with a potentially better tolerability profile
MR analysis suggested that the reduction in GLP-1 associated with HTH may be linked to alterations in the gut microbiome
Conclusions In conclusion, GLP-1-RAs present a safe, effective and well-tolerated treatment option for achieving significant weight loss in pwIIH, leading to headache improvement after six months as well