3 It was approved by the US FDA in 2023 to treat obesity (Zepbound , Eli Lilly and Company, Indianapolis, IN, USA) which was initially approved to treat type 2 diabetes in 2022 (Mounjaro , Eli Lilly and Company) (Table 1)
Theres ongoing research on long-term safety and continued efficacy and benefits seen among different populations
Dulaglutide decreased the hyperphosphorylation of tau and NFs proteins through improving the PI3K/Akt/GSK3 signaling pathway, which may be related to its protective effects on impaired of AD-like learning and memory (150)
These drugs were originally developed to treat type 2 diabetes, and worked by mimicking the natural hormones that lower blood sugar levels and slow down digestion
Because subcutaneous tissue has fewer blood vessels than muscle, the drug is absorbed gradually, which helps reduce sharp peaks and gives a smoother, more sustained effect