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31,278,279 In animal studies, mice with heterozygous knockout of miR-137 show repetitive behaviours and social behavioural deficits

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In contrast, coal-derived CQDs exhibited potent inhibition of SARS-CoV-2 replication in vitro , achieving more than 95% reduction in viral growth at half-maximal inhibitory concentration (IC 50 ) of approximately 5.47 g/mL, with minimal cytotoxicity in normal cell lines, indicating genuine antiviral activity in a human-relevant viral system [123]

Their small, linear structures facilitate easier synthesis, high water solubility, and effective diffusion across biological barriers

Different nodes represented distinct target proteins, and connections depicted their interaction relationships