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Produces a depletion of releasable neuronal monoamine neurotransmitters Reserpine's effects produce a reduction in blood pressure due to a decreased cardiac output & decreased peripheral vascular resistance Figure 1

3 , 4 , 5 , 6 , 7 , 8 An immunohistochemical study in a RP pig model suggested that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidative damage

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Next, the pellet was washed twice with 65 mM phosphate-buffered saline (PBS, pH = 7.8) and dried at 85 C to a constant weight