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Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival

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Table 5: Folic Acid Medication Table The table below is not an exhaustive list of all folic acid products and therapeutic considerations

Wang X, Liu L, Mou S, Zhao H, Fang J, Xiang Y, et al