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"In TRIUMPH-1 and TRANSCEND-T2D-1, treatment with retatrutide resulted in substantial weight reduction together with clinically meaningful improvements in glycemia, knee osteoarthritis pain, and obstructive sleep apnea, with many individuals reaching what are classified as healthy-range weight and normal blood sugar levels." On June 8 th , Lilly released results from its ACHIEVE Phase 3 trials that demonstrated that their daily oral GLP-1 drug, Foundayo (orforglipron), lowered A1C levels by A very large dataset of more than 2 million veterans revealed that GLP-1 drugs offer potentially significant benefits to neurological and behavioral health with reduced risks of addiction to substances such as alcohol, cannabis, stimulants and opioids, as well as a decreased risk of neurocognitive disorders such as Alzheimer's and dementia where they have evidenced reduced inflammation in the brain

All the authors have contributed significantly to the manuscript, per the International Committee of Medical Journal Editors criteria of authorship

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Oral formulations face unpredictable absorption in post-bariatric anatomy, which is why injectable compounded semaglutide or tirzepatide may be preferred choices for this patient population