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The model suggests an exchange with glutamate, but no mitochondrial GABA/glutamate exchanger is known in mammalian cells, although an exchanger has been demonstrated in plants (Michaeli et al., 2011), and the cell membrane of prokaryotes (which have no mitochondria) express a glutamateGABA exchanger, GadC (Ma et al., 2012)

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doi: 10.1038/s41598-021-97956-3 134 NewtonKStrasserAKayagakiNDixitVM

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15,16,18 Therefore, the replacement of glutathione with glutathione-mimicking compounds such as N -acetylcysteine serves as a useful antidote to acetaminophen toxicity