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Common side effects may include temporary skin irritation, mild redness, or sensitivity at application sites, particularly during initial treatment phases

Ethics statement The animal study was approved by the Experimental Animal Manage Committee of Changzhi Medical College (DW2024025)

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Vitamin B12, scientifically known as cobalamin, is a highly complex, water-soluble vitamin that is absolutely essential for human survival

Its ability to tightly and safely bind copper makes it a valuable subject of study in research exploring tissue remodeling, oxidative balance, and extracellular matrix dynamics