In ME/CFS patients, the scarcity of butyrate-producing bacteria could be due to low levels of SCFA, potentially causing post-exertional malaise and a cycle of inactivity
Ruscio AM, Stein DJ, Chiu WT, Kessler RC
Saudi Journal of Biological Sciences, 25(3), 493-499
Reactive intermediates resulting from lipid peroxidation (4hydroxynonenal), nucleotide peroxidation (adenine propenal) or catecholamine peroxidation (aminochrome, dopachrome, adrenochrome) are particularly inactivated by GSTs (DagninoSubiabre et al., 2000)
Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12