Daily supplement timing framework Morning with breakfast: Multivitamin, B-complex, vitamin D3 with K2 (with food containing fat), first protein serving, omega-3 (with food) Between meals: Protein shake as needed, electrolytes With lunch or dinner: Calcium citrate (first dose), iron (if prescribed, separate from calcium by 2 hours), zinc (with food) Evening: Magnesium glycinate (30 to 60 minutes before bed), calcium citrate (second dose if splitting), casein protein (optional bedtime shake), probiotics (bedtime on empty stomach) During dose escalation weeks The first one to two weeks after each dose increase typically bring the worst GI side effects
(2026) NHS [accessed 29 January 2026] Probiotics
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Injection Timing and Digestive Effects Because Mounjaro slows stomach emptying, some people may notice changes in medication tolerance or digestion during dose escalation
If nutrition falls off because appetite is virtually absent, fatigue can be severe
