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126 In addition to the general downregulation of 5-hmC content, focal DNA hyper-methylation of the promoters of some specific tumor suppressors has also been well illustrated in melanoma, in particular PTEN , P16 INK4A , P14 ARF , RASSF1A, and MGMT (occurring in ~60%, 30%, 80%, 55%, and 30% of melanomas, respectively) 127,128,129,130,131,132,133,134 (Fig

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