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In GLP-1R-MIN-6 cells, a high glucose (20 mM) level in the basal Gs activation state or 80 nM GLP-1 with a high glucose level stimulated insulin secretion, which was inhibited by H-89 and/or ESI-09

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The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

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Many of these compounds have been sold for decades in teas, powders, and pills with little to no meaningful impact on weight loss