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However, dysfunctional mitochondria are associated with impaired neuronal function and associated neurodegenerative diseases (187)

The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis

GLP-1 receptor agonists have become a leading treatment option for weight management, with clinical trials showing an average weight loss of 15-22% over 68 weeks

Conclusion The Phase I/II trial establishes MET-097i as a promising ultra-long-acting GLP-1 receptor agonist with the potential for monthly dosing and minimal titration