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However, biological PTM often results in non-homogeneous mixtures through non-uniform modification, posing complications for manufacturing and production (Chalker, Thiol-ene chemistry has been utilized in performing some of the most common naturally occurring PTMs through chemical modification, namely cyclization, glycosylation and lipidation

2-OHE2) results in a decreased cancer risk, whereas increased excretion of other metabolites (e.g., 16-hydroxylation metabolites and catechol estrogen DNA adducts) is associated with increased cancer risk 10,28,29

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